Biomedical Optics Lab



  1. Samaneh Rabienia Haratbar, Li Chen, Qiang Cheng, Dara Singh, Faraneh Fathi, Mehrana Mohtasebi, Xuhui Liu, Abhijit Patwardhan, Prasad Bhandary, Henrietta S. Bada, Guoqiang Yu & Elie G. Abu Jawdeh, "The impact of intermittent hypoxemia on type 1 retinopathy of prematurity in preterm infants," Nature Pediatric Research, pp. 1–7, Apr. 2024, doi: 10.1038/s41390-024-03169-5. Read Online Read pdf

  2. Xuhui Liu , Mehrana Mohtasebi , Pegah Safavi , Faraneh Fathi , Samaneh Rabienia Haratbar , Li Chen , Jin Chen , Henrietta S. Bada , Lei Chen , Elie G. Abu Jawdeh and Guoqiang Yu, "Wearable fiber-free optical sensor for continuous monitoring of neonatal cerebral blood flow and oxygenation," Nature Pediatric Research, pp. 1–8, Mar. 2024, doi: 10.1038/s41390-024-03137-z. Read Online Read pdf

  3. Mehrana Mohtasebi, Chong Huang, Mingjun Zhao, Siavash Mazdeyasna, Xuhui Liu, Samaneh Rabienia Haratbar, Faraneh Fathi, Jinghong Sun, Thomas Pittman, Guoqiang Yu, "A Wearable Fluorescence Imaging Device for Intraoperative Identification of Human Brain Tumors," IEEE Journal of Translational Engineering in Health and Medicine, vol. 12, pp. 225-232, 2024, doi: 10.1109/JTEHM.2023.3338564. Read Online Read Pdf


  1. Mehrana Mohtasebi, Dara Singh, Xuhui Liu, Faraneh Fathi, Samaneh Rabienia Haratbar, Kathryn E. Saatman, Lei Chen, Guoqiang Yu, "Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents," Neurophoton. 10(4) 045007 (14 November 2023). doi:10.1117/1.NPh.10.4.045007 Read Online Read Pdf
  2. M. Mohtasebi, D. Irwin, D. Singh, S. Mazdeyasna, X. Liu, S. R. Haratbar, F. Fathi, C. Huang, K. E. Saatman, L. Chen, G. Yu," Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography," Journal of Biomedical Optics, May 04, 2023-Volume 28, Issue 12, 121204.doi: 10.1117/1.JBO.28.12.121204. Read online


  1. S. Mazdeyasna, C. Huang, A.R. Bonaroti, M. Mohtasebi, Q. Cheng, L. Wong, G.Yu, "Intraoperative Optical and Fluorescence Imaging of Blood Flow Distributions in Mastectomy Skin Flaps for Identifying Ischemic Tissues," Plastic and Reconstructive Surgery: June 03, 2022 - Volume - Issue - 10.1097/PRS.0000000000009333 doi: 10.1097/PRS.0000000000009333. Read online Read pdf
  2. X. Liu; D. A. Irwin; C. Huang; Y. Gu; L. Chen; K. D. Donohue; L. Chen; G. Yu, "A Wearable Fiber-free Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Freely Behaving Mice," IEEE Transactions on Biomedical Engineering: 15 December 2022, Page(s): 1 - 11, DOI: 10.1109/TBME.2022.3229513 Read online
  3. D. Irwin, S. Mazdeyasna, C. Huang, M. Mohtasebi, X. Liu, L. Chen and G. Yu, Near-infrared Speckle Contrast Diffuse Correlation Tomography (scDCT) for Noncontact Imaging of Tissue Blood Flow Distribution: Book, CRC Press; 2022. Read more here.


  1. X. Liu, Y. Gu, C. Huang, M. Zhao, Y. Cheng, E. G. Abu Jawdeh, H. S. Bada, L. Chen, G. Yu, "Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor," J. Biomed. Opt. 26(1), 012705 (2021), doi: 10.1117/1.JBO.26.1.012705.  Read on-line   Read pdf

  2. M. Zhao, C. Huang, C. Huang, S. Mazdeyasna, G. Yu, "Extraction of tissue optical property and blood flow from speckle contrast diffuse correlation tomography (scDCT) measurements" Biomed. Opt. Express 12, 5894-5908 (2021).  Read on-line   Read pdf


  1. C. A. Wicker, V. Takiar, R. Suganya, S. M. Arnold, Y. M. Brill, L. Chen, C. M. Horbinski, D. Napier, J. Valentino, M. R. Kudrimoti, G. Yu, and T. Izumi, “Evaluation of antioxidant network proteins as novel prognostic biomarkers for head and neck cancer patients”, Oral Oncology (2020). PII: S1368-8375 (20) 30385-7  Read on-line

  2. A. A. Bahrani, W. Kong, Y. Shang, C. Huang, C. D. Smith, D. K. Powell, Y. Jiang, A. O. Rayapati, G. A. Jicha, G. Yu, "Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk", Journal of Biophotonics, (2020) Read on-line   Read pdf

  3. E. G. Abu Jawdeh*, C. Huang*, S. Mazdeyasna, L. Chen, L. Chen, H. S. Bada, G. Yu, "Noncontact optical imaging of brain hemodynamics in preterm infants: a preliminary study." Physics in Medicine and Biology (2020). 10.1088/1361-6560/abc5a7. Advance online publication. *Contributed equally. Read on-line   Read pdf

  4. C. Huang, S. Mazdeyasna, M. Mohtasebi, K. Saatman, Q. Cheng, G. Yu, L. Chen, "Speckle Contrast Diffuse Correlation Tomography (scDCT) of Cerebral Blood Flow in Perinatal Disease Model of Neonatal Piglets", Journal of Biophotonics, JBIO2662. DOI: 10.1002/jbio.202000366. Online ahead of print (2020) Read on-line   Read pdf


  1. M. Zhao, S. Mazdeyasna, C. Huang, N. Agochukwu, A. Bonaroti, L. Wong, G. Yu, “Noncontact speckle contrast diffuse correlation tomography of blood flow distributions in burn wounds: a preliminary study”,  Military Medicine, 2019 DOI:10.1093/milmed/usz233 Read pdf
  2. A. Bonaroti, R. C. DeCoster, S. Mazdeyasna, C. Huang, G. Yu, L. Wong, “The role of intraoperative laser speckle imaging in reducing postoperative complications in breast reconstruction”, Plastic and Reconstructive Surgery, Letter to the Editor, DOI: 10.1097/PRS.00000000000061242019 Read on-line   Read pdf
  3. T. Thomas, D. Schnell, M. Redzic, M. Zhao, H. Abraha, D. Jones, H. Brim, G. Yu, “Local in vivo measures of muscle lipid and oxygen consumption change in response to combined vitamin D repletion and aerobic training in older adults”, Nutrients, 11(4), 930 (2019) Read on-line  Read pdf
  4. C. Huang, S. Mazdeyasna, L. Chen, E. G. Abu Jawdeh, H. S. Bada, K. E. Saatman, L. Chen, G. Yu, “Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats”, NeuroImage, Volume 198, Pages 160-169 (2019) Read on-line  Read pdf


  1. S. Mazdeyasna, C. Huang, M. Zhao, N. B. Agochukwu, A. A. Bahrani, L. Wong, G. Yu, “Noncontact speckle contrast diffuse correlation tomography of blood flow distributions in tissues with arbitrary geometries”, Journal of Biomedical Optics, 23(9), 096005 (2018) Read on-line  Read pdf
  2. C. Huang, Y. Gu, J. Chen, A. A. Bahrani, E. G. Abu Jawdeh, H. S. Bada, K. Saatman, G. Yu, and L. Chen, “A wearable fiberless optical sensor for continuous monitoring of cerebral blood flow in mice”, IEEE Journal of Selected Topics in Quantum Electronics, 2018 Read on-line Read pdf
  3. A. A. Bahrani, O. M. Al-Janabi, G. Yu, D. M. Wilcock, C. D. Smith, G. A. Jicha, “Semi-Automated Volumetric Quantifying Method of Cerebral Microhemorrhage Using T2*-Weighted MRI Images”, Annals Of Neurology 84, S166, 2018 Read on-line


  1. C. Huang, D. Irwin, M. Zhao, Y. Shang, N. B. Agochukwu, L. Wong, G. Yu, “Noncontact 3-dimensional speckle contrast diffuse correlation tomography of tissue blood flow distribution”, IEEE Transactions on Medical Imaging, 36(10), 2017 Read on-line  Read pdf  Appendix
  2. N. B. Agochukwu*, C. Huang*, M. Zhao, A. Bahrani, L. Wong, G. Yu, “A novel noncontact diffuse correlation spectroscopy for assessing blood flow in mastectomy skin flaps: a prospective study in patients undergoing prosthesis-based reconstruction”, Plastic and Reconstructive Surgery, 140(1), 2017. *Contributed equally. Read on-line  Read pdf
  3. A. A. Bahrani, D. K. Powell, G. Yu, E. S. Johnson, G. A. Jicha, C. D. Smith, “White matter hyperintensity associations with cerebral blood flow in elderly subjects stratified by cerebrovascular risk”, Journal of Stroke, 26(4), 2017  Read on-line  Read pdf
  4. Y. ShangT. Li and G. Yu, “Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging”, Physiological Measurement, 38(4), 2017. Read on-line  Read pdf


  1. L. Dong, M. Kudrimoti, D. Irwin, L. Chen, S. Kumar, Y. Shang, C. Huang, E. Johnson, S. Stevens, B. Shelton, G. Yu, “Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemo-radiation therapy outcomes,” Journal of Biomedical Optics, 21(8), 085004 (2016)  Read on-line  Read pdf
  2. C. Huang, M. Seong, J. P. Morgan, S. Mazdeyasna, J. G. Kim, J. T. Hastings, G. Yu, “A low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device,” Journal of Biomedical Optics Letters, 21(8), 080501 (2016) Read on-line  Read pdf


  1. B. Henry*, M. Zhao*, Y. Shang, T. Uhl, D. T. Thomas, E. S. Xenos, S. P. Saha, G. Yu, “Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise,” Journal of Biomedical Optics, 20(12), 125006 (2015). *Contributed equally.  Read on-line   Read pdf
  2. C. Huang, Y. Lin, L. He, D. Irwin, M. Szabunio, G. Yu, “Alignment of Sources and Detectors on Breast Surface for Noncontact Diffuse Correlation Tomography of Breast Tumors,” Applied Optics, 54(29) 8808-8816 (2015).  Read on-line   Read pdf
  3. T. Li, M. Duan, K. Li, G. Yu, and Z. Ruan, “Bedside monitoring of patients with shock using a portable spatially-resolved near-infrared spectroscopy,” Biomedical Optics Express, Vol. 6, Issue 9, 3431-3436 (2015).  Read on-line   Read pdf
  4. L. He, Y. Lin, C. Huang, D. Irwin, M. M. Szabunio, G. Yu, “Noncontact Diffuse Correlation Tomography of Human Breast Tumor,” Journal of Biomedical Optics, 20(8),086003 (2015).  Read on-line  Read pdf
  5. C. Huang, J. P. Radabaugh, R. K. Aouad, Y. Lin, T. J. Gal, A. B. Patel, J. Valentino, Y. Shang, G. Yu, “Noncontact Diffuse Optical Assessment of Blood Flow Changes in Head and Neck Free Tissue Transfer Flaps,” Journal of Biomedical Optics, 20(7), 075008 (2015). Read on-line  Read pdf
  6. C. Huang*, D. Irwin*, Y. Lin, Y. Shang, L. He, W. Kong, J. Luo, G. Yu, “Speckle contrast diffuse correlation tomography of complex turbid medium flow,” Medical Physics Letter, 42(7), 4000 (2015). *Contributed equally. Read on-line  Read pdf


  1. Y. Shang and G. Yu, “A Nth-order linear algorithm for extracting diffuse correlation spectroscopy blood flow indices in heterogeneous tissues,” Applied Physics Letters, 105, 133702 (2014). Read on-line  Read pdf
  2. Y. Hou*, Y. Shang*, R. Cheng, Y. Zhao, Y. Qin, R. Kryscio, A. Rayapati, D. Hayes Jr, G. Yu, “Obstructive sleep apnea–hypopnea results in significant variations in cerebral hemodynamics detected by diffuse optical spectroscopies,” Physiological Measurement, 35, 2135 (2014). *Contributed equally. Read on-line  Read pdf
  3. Y. Shang, T. Li, L. Chen, Y. Lin, M. Toborek, G. Yu, “Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation,” Applied Physics Letters, 104, 193703 (2014). Read on-line  Read pdf
  4. Y. Lin*, C. Huang*, D. Irwin, L. He, Y. Shang, G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Applied Physics Letters, 104, 121103 (2014). *Contributed equally. Read on-line  Read pdf
  5. X. Zhang*, R. Cheng*, D. Rowe, P. Sethu, A. Daugherty, G. Yu and H. Y. Shin “Shear-Sensitive Regulation of Neutrophil Flow Behavior and Its Potential Impact on Microvascular Blood Flow Dysregulation in Hypercholesterolemia,” Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), 587 (2014). *Contributed equally. Read on-line  Read pdf
  6. R. Cheng, Y. Shang, S. Wang, J. M. Evans, A. Rayapati, D. C. Randall, G. Yu, “Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope”, Journal of Biomedical Optics 19(1), 017001 (2014). Read on-line  Read pdf


  1. Y. Shang, K. Gurley, G. Yu, “Diffuse Correlation Spectroscopy (DCS) for Assessment of Tissue Blood Flow in Skeletal Muscle: Recent Progress,” Anatomy & Physiology, 3(2), 1000128, Invited Review (2013). Read on-line  Read pdf
  2. R. Cheng*, X. Zhang*, A. Daugherty, H. Shin, G. Yu, “Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy,” Applied Optics, 52(30), 7324 (2013). *Contributed equally. Read on-line  Read pdf
  3. Y. Shang, Y. Lin, B. A. Henry, R. Cheng, C. Huang, L. Chen, B. J. Shelton, K. R. Swartz, S. S. Salles, G. Yu, “Noninvasive evaluation of electrical stimulation impacts on muscle hemodynamics via integrating diffuse optical spectroscopies with muscle stimulator,” Journal of Biomedical Optics, 18(10), 105002 (2013). Read on-line  Read pdf
  4. T. Li*, Y. Lin*, Y. Shang, L. He, C. Huang, M. Szabunio, G. Yu, “Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter,” Scientific Reports, 3, 1358 (2013). *Contributed equally. Read on-line   Read pdf
  5. L. Dong, L. He, Y. Lin, Y. Shang, G. Yu, “Simultaneously extracting multiple parameters via fitting one single autocorrelation function curve in diffuse correlation spectroscopy,” IEEE Transactions on Biomedical Engineering, 60(2), 361 (2013). Read on-line   Read pdf
  6. R. Srikuea, T. B. Symons, D. E. Long, J. Lee, Y. Shang, P. J. Chomentowski, G. Yu, L. J. Crofford, C. A. Peterson, “Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women,” Arthritis & Rheumatism, 65(2), 519 (2013). Read on-line   Read pdf
  7. L. He, Y. Lin, Y. Shang, B. Shelton, G. Yu, “Using optical fibers with different modes to improve the signal-to-noise ratio (SNR) of diffuse correlation spectroscopy (DCS) flow-oximeter measurements,” Journal of Biomedical Optics, 18(3), 037001 (2013) Read on-line  Read pdf
  8. R. C. Mesquita, M. Putt, M. Chandra, G. Yu, X. Xing, S. W. Han, G. Lech, Y. Shang, T. Durduran, C. Zhou, A. G. Yodh, E. R. Mohler, III, “Diffuse optical characterization of an exercising patient group with peripheral artery disease,” Journal of Biomedical Optics, 18(5), 057007 (2013). Read on-line   Read pdf
  9. G. Yu, R. Cheng, J. Yang, Z. Yang, M. Xun, T. Liu, Y. Li, “Near-infrared  diffuse  correlation spectroscopy (DCS) for noninvasive monitoring of photodynamic therapy (PDT),” International  Journal of Biomedical Engineering, 36(3), 134-138, Invited Review (2013).


  1. Y. Shang, K. Gurley, B. Symons, D. Long, R. Srikuea, L. J. Crofford, C. A. Peterson, G. Yu, “Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia,” Arthritis Research & Therapy, 14(6), R236 (2012)  Read on-line  Read pdf
  2. K. Gurley, Y. Shang, G. Yu, “Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle,” Journal of Biomedical Optics, 17, 075010 (2012)   Read on-line Read pdf
  3. R. Cheng, Y. Shang, D. Hayes, S. Saha, G. Yu, “Noninvasive optical evaluation of spontaneous low frequency oscillations in cerebral hemodynamics,” NeuroImage, 62(3), 1445-1454 (2012)  Read on-line   Read pdf
  4. L. Dong, M. Kudrimoti, R. Cheng, Y. Shang, E. L. Johnson, S. D. Stevens, B. J. Shelton, G. Yu, “Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery,” Biomedical Optics Express, 3, 259-272 (2012) (highlighted as spotlight paper)  Read on-line  Read pdf
  5. Y. Lin, L. He, Y. Shang, G. Yu, “Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement,” Journal of Biomedical Optics Letters, 17(2), 010502 (2012) Read on-line  Read pdf
  6. N. Munk, B. Symons, Y. Shang, R. Cheng, G. Yu, “Noninvasively measuring the hemodynamic effects of massage on skeletal muscle: a novel hybrid near-Infrared diffuse optical instrument,” Journal of Bodywork & Movement Therapies, 16(1), 22-28 (2012) Read on-line  Read pdf
  7. G. Yu, “Near-infrared diffuse correlation spectroscopy (DCS) in cancer diagnosis and therapy monitoring,” Journal of Biomedical Optics 17(2), 010901 (2012) Read on-line  Read pdf
  8. G.Yu, “Diffuse Correlation Spectroscopy (DCS): A Diagnostic Tool for Assessing Tissue Blood Flow in Vascular-Related Diseases and Therapies,” Current Medical Imaging Reviews, 8(3), 194-210 (2012) Read pdf
  9. G. Yu, “Near-infrared diffuse correlation spectroscopy (DCS) for assessing deep tissue blood flow,” Anatomy and Physiology (invited editorial article), 2(2), 1000e115 (2012) Read pdf
  10. L. Chen, Y. Shang, E. Sipos, K. E. Saatman, G. Yu, M Toborek, “Novel experimental model for repeated forebrain ischemia-reperfusion,” Journal of experimental stroke and translational medicine, 5(1), 1-10 (2012) Read on-line  Read pdf
  11. A. L. Maas, S. L. Carter, E. P. Wileyto, J. Miller, M. Yuan, G. Yu, A. Durham, T. M. Busch, “The tumor vascular microenvironment determines responsiveness to photodynamic therapy,” Cancer Research, 72(8), 2079-88 (2012) Read on-line  Read pdf


  1. Y. Shang, L. Chen, M Toborek, G. Yu, “Diffuse optical monitoring of repeated cerebral ischemia in mice,” Optics Express 19, 20301-20315 (2011) (highlighted by Virtual Journal for Biomedical Optics) Read on-line  Read pdf
  2. D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, G. Yu, “Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements,” Biomedical Optics Express, 2, 1969–1985 (2011)  Read on-line  Read pdf
  3. Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Physics in Medicine and Biology, 56,3015–3032 (2011)  Read on-line  Read pdf
  4. G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, S. P. Saha, “Intraoperative Evaluation of Revascularization Effect on Ischemic Muscle Hemodynamics Using Near-infrared Diffuse Optical Spectroscopies,” Journal of Biomedical Optics, 16(2), 027004 (2011) (highlighted by Virtual Journal of Biological Physics Research)  Read on-line  Read pdf
  5. G. Yu, T. Durduran, C. Zhou, R. Cheng, A. G. Yodh, “Near-infrared diffuse correlation spectroscopy (DCS) for assessment of tissue blood flow,” Chapter 10, Handbook of Biomedical Optics, D.A. Boas, C. Pitris, and N. Ramanujam Editors, Taylor & Francis Books Inc, page:195-216 (2011)  Read pdf
  6. R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, A. G. Yodh, “Direct measurement of tissue blood flow & metabolism with diffuse optics,” Phil. Trans. R. Soc. A 369, 4390–4406 (2011)  Read on-line  Read pdf


  1. Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, G. Yu, “Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise,” Biomedical Optics Express, 1, 500-511 (2010)  Read on-line  Read pdf
  2. T. M. Busch, H. W. Wang, E. P Wileyto, G. Yu, R. M. Bunte, “Increasing damage to tumor blood vessels during vascular-targeting PDT through use of low fluence rate,” Radiation Research, 0033-7587/10 (2010)  Read on-line  Read pdf
  3. T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, W. J. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, D. J. Licht. “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” Journal of Biomedical Optics, 15(3):037004 (2010)  Read on-line  Read pdf
  4. M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit Care, 12(2): 173-180 (2010)  Read on-line  Read pdf


  1. Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Optics Letters, 34(22), 3556-3558 (2009) (highlighted by Virtual Journal of Biological Physics Research)  Read on-line  Read pdf
  2. T. M. Busch, X. Xing, G. Yu, A. G. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, K. K.H. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to photofrin photodynamic therapy,” Photochemistry & Photobiology Science,  8: 1683-1693 (2009)  Read on-line  Read pdf
  3. C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” Journal of Biomedical Optics, 14(3):034015 (2009)  Read on-line  Read pdf
  4. T. Durduran, C. Zhou, L. E. Brian, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, J. A. Detre, “Transcranial optical monitoring of cerebral blood flow and hemoglobin concentration in acute stroke patients during positional interventions,” Annals of Neurology, Optics Express, 17(5):3884-3902 (2009)  Read on-line  Read pdf
  5. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, A. G. Yodh. “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial doppler ultrasound,” Optics Express, 17(15):12571-12581 (2009)  Read on-line  Read pdf


  1. C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” Journal of Cerebral Blood Flow & Metabolism 28(7), 1275-1284 (2008) Read on-line  Read pdf


  1.  G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. A. Detre, A. G. Yodh, “Diffuse correlation spectroscopy for muscle blood flow: validation with arterial-spin-labeling perfusion MRI,” Optics Express, 15:1064-1075 (2007)  Read on-line  Read pdf
  2. U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Optics Express, 15(23), 15507-15516 (2007)  Read on-line  Read pdf
  3. C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer du ring early stages of neoadjuvant chemotherapy,” Journal of Biomedical Optics, 12(5), 051903 (2007)  Read on-line  Read pdf


  1. C. Zhou, G. Yu, D. Furuya, J. A. Detre, J. H. Greenberg, A. G. Yodh, T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Optics Express 24(3), 1125-1144 (2006)  Read on-line  Read pdf
  2. G. Yu, T. Durduran, C. Zhou, T. C. Zhu, J. C. Finlay, T. M. Busch, S. B. Malkowicz, S. M. Hahn, A. G. Yodh, “Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light,” Photochemistry & Photobiology, 82(5), 1279-1284 (2006)  Read on-line  Read pdf
  3. U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” Journal of Biomedical Optics, 11(6), 064021 (2006)  Read on-line  Read pdf
  4. K. L. Du, R. Mick, T. M. Busch, T. C. Zhu, J. C. Finlay, G. Yu, A. G. Yodh, S. B. Malkowicz, D. Smith, R. Whittington, D. Stripp, S. M. Hahn, “Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer,” Lasers in Surgery and Medicine, 38(5), 427-434 (2006)  Read on-line  Read pdf


  1. G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clinical Cancer Research, 11(9), 3543-3552 (2005)  Read on-line  Read pdf
  2. G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, 3rd, A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” Journal of Biomedical Optics, 10(2), 024027 (2005)  Read on-line  Read pdf
  3. T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Optics Letters, 30(21), 2915-2917 (2005)  Read on-line  Read pdf


  1. T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Optics Letters, 29(15), 1766-1768 (2004)  Read on-line  Read pdf
  2. T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” Journal of Cerebral Blood Flow & Metabolism, 24(5), 518-525 (2004)  Read on-line  Read pdf


  1. G. Yu, T. Durduran, D. Furuya, J. H. Greenberg, A. G. Yodh, “Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics,” Applied Optics, 42(16), 2931-2939 (2003)  Read on-line  Read pdf
  2. R. Choe, T. Durduran, G. Yu, M. J. Nijland, B. Chance, A. G. Yodh, N. Ramanujam, “Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero,” Proc Natl Acad Sci (PNAS), 100(22), 12950-12954 (2003)  Read on-line  Read pdf